Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model.

ABSTRACT: Decompensated right ventricular failure (RVF) in patients with pulmonary hypertension (PH) is fatal, with limited treatment options. Novel mechanical circulatory support systems have therapeutic potential for RVF, but the development of these devices requires a large animal disease model that replicates the pathophysiology observed in humans. We previously reported an effective disease model of PH in sheep through ligation of the left pulmonary artery (PA) and progressive occlusion of the main PA. Herein, we report a case of acute decompensation with this model of chronic RVF. Gradual PA banding raised the RV pressure (maximum RV systolic/mean pressure = 95 mmHg/56 mmHg). Clinical findings and laboratory serum parameters suggested appropriate physiologic compensation for 7 weeks. However,

SUBMITTER: Ukita R 

PROVIDER: S-EPMC8523569 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature