Dietary factors and risk of islet autoimmunity and type 1 diabetes: a systematic review and meta-analysis.

ABSTRACT:

Background

Numerous dietary components have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D); however, no associations are firmly established. This systematic review and meta-analysis aimed to synthesize current knowledge on diet and incidence of IA and T1D.

Methods

Literature search was performed in Medline, Embase, and Cochrane Library, from inception until October 2020. Eligible studies had IA or T1D as outcome; any dietary exposure; case-control, cohort, or randomized controlled trial design; and hazard, risk, or odds ratios as measures of association. Summary relative risks (RR) and 95% confidence intervals (CI) were estimated with random-effects models. Certainty of evidence was assessed with GRADE. PROSPERO registration number: CRD42

SUBMITTER: Lampousi AM 

PROVIDER: S-EPMC8523874 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature