Dynamic ¹⁸F-FDopa PET Imaging for Newly Diagnosed Gliomas: Is a Semiquantitative Model Sufficient?

ABSTRACT:

Purpose

Dynamic amino acid positron emission tomography (PET) has become essential in neuro-oncology, most notably for its prognostic value in the noninvasive prediction of isocitrate dehydrogenase (IDH) mutations in newly diagnosed gliomas. The 6-[¹⁸F]fluoro-l-DOPA (¹⁸F-FDOPA) kinetic model has an underlying complexity, while previous studies have predominantly used a semiquantitative dynamic analysis. Our study addresses whether a semiquantitative analysis can capture all the relevant information contained in time-activity curves for predicting the presence of IDH mutations compared to the more sophisticated graphical and compartmental models.

Methods

Thirty-seven tumour time-activity curves from ¹⁸F-FDOPA PET dynamic acquisitions of newly

SUBMITTER: Zaragori T 

PROVIDER: S-EPMC8523996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature