Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers.

ABSTRACT:

Purpose

NUF2 has been implicated in multiple cancers recently, suggesting NUF2 may play a role in the common tumorigenesis process. In this study, we aim to perform comprehensive meta-analysis of NUF2 expression in the cancer types included in the Cancer Genome Atlas (TCGA).

Materials and methods

RNA-sequencing data in 31 cancer types in the TCGA data and 11 independent datasets were used to examine NUF2 expression. Silencing NUF2 using targeting shRNAs in hepatocellular carcinoma (HCC) cell lines was used to evaluate NUF2's role in HCC in vitro and in vivo.

Results

NUF2 up-regulation is significantly observed in 23 out of the 31 cancer types in the TCGA datasets and validated in 13 major cancer types using 11 independent datasets. NUF2 overexpression was clinically i

SUBMITTER: Jiang X 

PROVIDER: S-EPMC8524009 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature