Challenges in Detection of Serum Oncoprotein: Relevance to Breast Cancer Diagnostics.

ABSTRACT: Breast cancer is a highly prevalent malignancy that shows improved outcomes with earlier diagnosis. Current screening and monitoring methods have improved survival rates, but the limitations of these approaches have led to the investigation of biomarker evaluation to improve early diagnosis and treatment monitoring. The enzyme-linked immunosorbent assay (ELISA) is a specific and robust technique ideally suited for the quantification of protein biomarkers from blood or its constituents. The continued clinical relevancy of this assay format will require overcoming specific technical challenges, including the ultra-sensitive detection of trace biomarkers and the circumventing of potential assay interference due to the expanding use of monoclonal antibody (mAb) therapeutics. Approaches to incr

SUBMITTER: Lengfeld J 

PROVIDER: S-EPMC8524259 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature