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ABSTRACT:
SUBMITTER: Asin-Garcia E
PROVIDER: S-EPMC8524654 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Asin-Garcia Enrique E Martin-Pascual Maria M Garcia-Morales Luis L van Kranenburg Richard R Martins Dos Santos Vitor A P VAP
ACS synthetic biology 20210922 10
Genome recoding enables incorporating new functions into the DNA of microorganisms. By reassigning codons to noncanonical amino acids, the generation of new-to-nature proteins offers countless opportunities for bioproduction and biocontainment in industrial chassis. A key bottleneck in genome recoding efforts, however, is the low efficiency of recombineering, which hinders large-scale applications at acceptable speed and cost. To relieve this bottleneck, we developed ReScribe, a highly optimized ...[more]