Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.

ABSTRACT: Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We have characterized motile ciliated cells within the zebrafish brain ventricles. We show that the ventricles undergo restructuring through development, involving a transition from mono- to multiciliated cells (MCCs) driven by gmnc. MCCs co-exist with monociliated cells and generate directional flow patterns. These ciliated cells have different developmental origins and are genetically heterogenous with respect to expression of the Foxj1 family of ciliary master regulators. Finally, we show that cilia loss from the tela choroida and choroid plexus or glo

SUBMITTER: D'Gama PP 

PROVIDER: S-EPMC8524669 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature