Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics.

ABSTRACT: LINE-1 retrotransposon, the most active mobile element of the human genome, is subject to tight regulatory control. Stressful environments and disease modify the recruitment of regulatory proteins leading to unregulated activation of LINE-1. The activation of LINE-1 influences genome dynamics through altered chromatin landscapes, insertion mutations, deletions, and modulation of cellular plasticity. To date, LINE-1 retrotransposition has been linked to various cancer types and may in fact underwrite the genetic basis of various other forms of chronic human illness. The occurrence of LINE-1 polymorphisms in the human population may define inter-individual differences in susceptibility to disease. This review is written in honor of Dr Peter Stambrook, a friend and colleague who carried out h

SUBMITTER: Ramos KS 

PROVIDER: S-EPMC8524765 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature