The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity.

ABSTRACT: The hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like control animals, those with hippocampal lesions exhibit potentiation of visually evoked potentials after passive daily exposure to a phase-reversing oriented grating stimulus, which is accompanied by long-term habituation of a reflexive behavioral response. Thus, low-level recognition memory is formed independently of the hippocampus. However, response potentiation resulting from daily exposure to a fixed sequence of four oriented gratings is severely impaired in mice with hippocampal damage. A feature of sequence plasticity in V1 of controls,

SUBMITTER: Finnie PSB 

PROVIDER: S-EPMC8524775 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature