Frailty transitions, inflammation, and mortality among persons aging with HIV infection and injection drug use.

ABSTRACT:

Objective

Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stress, predictive of major adverse clinical outcomes in HIV-infected and uninfected adults. Frailty is a dynamic state, yet little data exist on predictors and consequences of frailty transitions.

Design/methods

Frailty was assessed semiannually among HIV-infected and uninfected persons with prior injection drug use using the five Fried phenotype domains. An inflammatory index score was constructed from IL-6 and soluble TNF-α receptor-1 data. Markov transition models assessed determinants of frailty transitions. Cox proportional hazards models estimated mortality risk.

Results

Among 1353 AIDS Linked to the IntraVenous Experience participants

SUBMITTER: Piggott DA 

PROVIDER: S-EPMC8524776 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature