Mapping Mechanical Properties of the Tumor Microenvironment by Laser Speckle Rheological Microscopy.

ABSTRACT: Altered mechanical properties of the tumor matrix have emerged as both the cause and consequence of breast carcinogenesis. Increased tumor stiffness has traditionally provided a viable metric to screen for malignancies via palpation or imaging. Previous studies have demonstrated that the microscale mechanical properties of the cell substrate influence tumor proliferation and invasive migration in vitro. Nevertheless, the association of the mechanical microenvironment with clinical hallmarks of aggressiveness in human breast tumors, including histopathological subtype, grade, receptor expression status, and lymph node involvement is poorly understood. This is largely due to the lack of tools for mapping tumor viscoelastic properties in clinical specimens with high spatial resolution

SUBMITTER: Hajjarian Z 

PROVIDER: S-EPMC8524785 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature