Prevalence of drug-drug interactions in older people before and after hospital admission: analysis from the OPERAM trial.

ABSTRACT:

Background

Drug-drug interactions (DDIs) are highly prevalent in older patients but little is known about prevalence of DDIs over time. Our main objective was to assess changes in the prevalence and characteristics of drug-drug interactions (DDIs) during a one-year period after hospital admission in older people, and associated risk factors.

Methods

We conducted a sub-study of the European OPERAM trial (OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people), which assessed the effects of a structured medication review (experimental arm) compared to usual care (control arm) on reducing drug-related hospital readmissions. All OPERAM patients (≥70 years, with multimorbidity and polypharmacy, hospitalized in four centers in Bern, Brussels, Cork

SUBMITTER: Zerah L 

PROVIDER: S-EPMC8524798 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature