Extracorporeal carbon dioxide removal for treatment of exacerbated chronic obstructive pulmonary disease (ORION): study protocol for a randomised controlled trial.

ABSTRACT:

Background

Hypercapnic exacerbations are severe complications of chronic obstructive pulmonary disease (COPD), characterized by negative impact on prognosis, quality of life and healthcare costs. The present standard of care for acute exacerbations of COPD is non-invasive ventilation; when it fails, the use of invasive mechanical ventilation is inevitable, but is associated with extremely poor prognosis. Extracorporeal circuits designed to remove CO₂ (ECCO₂R) may enhance the efficacy of NIV to remove CO₂ and avoid the worsening of respiratory acidosis, which inevitably leads to failure of non-invasive ventilation. Although the use of ECCO₂R for acute exacerbations of COPD is steadily increasing, solid evidence on its efficacy and safety i

SUBMITTER: Tonetti T 

PROVIDER: S-EPMC8524839 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature