Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling.
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ABSTRACT:
SUBMITTER: Chen XY
PROVIDER: S-EPMC8524846 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling.
Chen Xi-Yao XY Jiao Yang Y Zhang Fu-Yang FY
Military Medical Research 20211019 1
The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury. ...[more]
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2021-12-30 | GSE192643 | GEO