Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling.

ABSTRACT: The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.

SUBMITTER: Chen XY 

PROVIDER: S-EPMC8524846 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature