Dual inhibition of α_vβ₆ and α_vβ₁ reduces fibrogenesis in lung tissue explants from patients with IPF.

ABSTRACT:

Rationale

α_v integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (α_vβ₆) and fibroblasts (α_vβ₁) in fibrotic lungs.

Objectives

We evaluated multiple α_v integrin inhibition strategies to assess which most effectively reduced fibrogenesis in explanted lung tissue from patients with idiopathic pulmonary fibrosis.

Methods

Selective α_vβ₆ and α_vβ₁, dual α_vβ₆/α_vβ₁, and multi-α_v integrin inhibitors were characterized for potency, selectivity, and functional activity by ligand binding, cell adhesion,

SUBMITTER: Decaris ML 

PROVIDER: S-EPMC8524858 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature