Serum uric acid and risk of incident chronic kidney disease: a national cohort study and updated meta-analysis.

ABSTRACT:

Background

We prospectively examined the association between serum uric acid (SUA) levels and chronic kidney disease (CKD) in China and updated the evidence through a comprehensive meta-analysis of prospective studies worldwide.

Methods

Our original analyses were based on data from the China Health and Retirement Longitudinal Study. The primary exposure of interest was SUA at baseline, and the main outcome was incident CKD. Logistic regression models were used to examine the association between SUA levels and incident CKD. A meta-analysis was performed to pool our effect estimate and those from other cohort studies.

Results

During a 4-year follow-up, 180 participants developed incident CKD. Participants in the highest SUA quartile were 2.73 times as likely to develop

SUBMITTER: Wu N 

PROVIDER: S-EPMC8524911 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature