TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study.

ABSTRACT:

Background

Breast cancer chemoresistance is attributed to a wide variety of mechanisms, including autophagy. Transcription factor EB (TFEB) has been recently identified and characterized as one major regulator of autophagy and lysosomal genesis.

Objective

This study aims to evaluate the prognostic impact of TFEB and its pathway in breast cancer chemoresistance.

Methods

This retrospective study analyzes the expression of TFEB, CARM1, SIRT1, and Beclin-1 and the methylation of PITX2 in breast carcinoma. A group of breast cancer patients treated with chemotherapy, who relapsed within 12 months from treatment initiation, were compared to a sub-cohort of chemo-treated patients who did not recur within 12 months of follow-up. The expression of TFEB, CARM1, SIRT1, and Belcin

SUBMITTER: Bertozzi S 

PROVIDER: S-EPMC8524961 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature