Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.

ABSTRACT:

Background

Non-coding regulatory elements (NCREs), such as enhancers, play a crucial role in gene regulation, and genetic aberrations in NCREs can lead to human disease, including brain disorders. The human brain is a complex organ that is susceptible to numerous disorders; many of these are caused by genetic changes, but a multitude remain currently unexplained. Understanding NCREs acting during brain development has the potential to shed light on previously unrecognized genetic causes of human brain disease. Despite immense community-wide efforts to understand the role of the non-coding genome and NCREs, annotating functional NCREs remains challenging.

Methods

Here we performed an integrative computational analysis of virtually all currently available epigenome data sets r

SUBMITTER: Yousefi S 

PROVIDER: S-EPMC8524963 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature