Plasmodium falciparum clearance time in Malawian children with cerebral malaria: a retrospective cohort study.

ABSTRACT:

Background

Standard treatment for both uncomplicated and severe malaria is artemisinin derivatives. Delayed parasite clearance times preceded the appearance of artemisinin treatment failures in Southeast Asia. Most worldwide malaria cases are in sub-Saharan Africa (SSA), where clinically significant artemisinin resistance or treatment failure has not yet been detected. The recent emergence of a resistance-conferring genetic mutation in the Plasmodium falciparum parasite in Africa warrants continued monitoring throughout the continent.

Methods

An analysis was performed on data from a retrospective cohort study of Malawian children with cerebral malaria admitted between 2010 and 2019 to a public referral hospital, ascertaining parasite clearance times across years. Data were c

SUBMITTER: Saidi AM 

PROVIDER: S-EPMC8524966 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature