Ontology highlight
ABSTRACT:
SUBMITTER: Stasik S
PROVIDER: S-EPMC8525221 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Stasik Sebastian S Eckardt Jan-Niklas JN Kramer Michael M Röllig Christoph C Krämer Alwin A Scholl Sebastian S Hochhaus Andreas A Crysandt Martina M Brümmendorf Tim H TH Naumann Ralph R Steffen Björn B Kunzmann Volker V Einsele Hermann H Schaich Markus M Burchert Andreas A Neubauer Andreas A Schäfer-Eckart Kerstin K Schliemann Christoph C Krause Stefan S Herbst Regina R Hänel Mathias M Frickhofen Norbert N Noppeney Richard R Kaiser Ulrich U Baldus Claudia D CD Kaufmann Martin M Rácil Zdenek Z Platzbecker Uwe U Berdel Wolfgang E WE Mayer Jiri J Serve Hubert H Müller-Tidow Carsten C Ehninger Gerhard G Bornhäuser Martin M Schetelig Johannes J Middeke Jan M JM Thiede Christian C
Blood advances 20210901 17
The tyrosine-protein phosphatase nonreceptor type 11 (PTPN11) is an important regulator of RAS signaling and frequently affected by mutations in patients with acute myeloid leukemia (AML). Despite the relevance for leukemogenesis and as a potential therapeutic target, the prognostic role is controversial. To investigate the prognostic impact of PTPN11 mutations, we analyzed 1529 adult AML patients using next-generation sequencing. PTPN11 mutations were detected in 106 of 1529 (6.93%) patients (m ...[more]