Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted.

ABSTRACT: Infection with adenoviruses is a common and significant complication in pediatric patients after allogeneic hematopoietic stem cell transplantation. Treatment options with traditional antivirals are limited by poor efficacy and significant toxicities. T-cell reconstitution is critical for the management of adenoviral infections, but it generally takes place months after transplantation. Ex vivo-generated virus-specific T cells (VSTs) are an alternative approach for viral control and can be rapidly generated from either a stem cell donor or a healthy third-party donor. In the context of a single-center phase 1/2 clinical trial, we treated 30 patients with a total of 43 infusions of VSTs for adenoviremia and/or adenoviral disease. Seven patients received donor-derived VSTs, 21 patients recei

SUBMITTER: Rubinstein JD 

PROVIDER: S-EPMC8525242 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature