Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System.

ABSTRACT: Glial cells (astrocytes, oligodendrocytes, and microglia) are emerging as key players in several physiological and pathological processes of the central nervous system (CNS). Astrocytes and oligodendrocytes are not only supportive cells that release trophic factors or regulate energy metabolism, but they also actively modulate critical neuronal processes and functions in the tripartite synapse. Microglia are defined as CNS-resident cells that provide immune surveillance; however, they also actively contribute to shaping the neuronal microenvironment by scavenging cell debris or regulating synaptogenesis and pruning. Given the many interconnected processes coordinated by glial cells, it is not surprising that both acute and chronic CNS insults not only cause neuronal damage but also trigger

SUBMITTER: Meneghini V 

PROVIDER: S-EPMC8525379 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature