Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.

ABSTRACT:

Objective

Memory dysfunction is prevalent in many neurological disorders and can have a significant negative impact on quality of life. The genetic contributions to memory impairment in epilepsy, particularly temporal lobe epilepsy (TLE), remain poorly understood. Here, we compare the brain transcriptome between TLE patients with and without verbal memory impairments to identify genes and signaling networks important for episodic memory.

Methods

Brain tissues were resected from 23 adults who underwent dominant temporal lobectomy for treatment of pharmacoresistant epilepsy. To control for potential effects of APOE on memory, only those homozygous for the APOE ε3 allele were included. A battery of memory tests was performed, and patients were stratified into two groups based o

SUBMITTER: Busch RM 

PROVIDER: S-EPMC8525612 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature