Generation and persistence of S1 IgG and neutralizing antibodies in post-COVID-19 patients.

ABSTRACT:

Background

Antibody-mediated immune response plays an important role in protection against reinfection. In the case of SARS-CoV-2 infection, the maximum duration of antibody response is still unknown. In this work, the generation of neutralizing  antibodies (NAbs) and IgG antibodies against the S1 subunit (S1 IgG ) of SARS-CoV-2 and their possible duration were determined through decay models.

Methods

132 participants with SARS-CoV-2 infection were classified according to the severity of the disease. Seroconversion and persistence of S1 IgG antibodies and NAbs were determined by ELISA, samples were taken at two different times post-infection and duration of those antibodies was estimated using Linear Mixed Models (LMMs).

Results

The highest amount of S1 IgGs antibodie

SUBMITTER: Guzman-Martinez O 

PROVIDER: S-EPMC8525617 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature