Neutrophil Extracellular Traps (NETs): Opportunities for Targeted Therapy.

ABSTRACT: Antitumor therapy, including adoptive immunotherapy, inevitably faces powerful counteraction from advanced cancer. If hematological malignancies are currently amenable to therapy with CAR-T lymphocytes (T-cells modified by the chimeric antigen receptor), solid tumors, unfortunately, show a significantly higher degree of resistance to this type of therapy. As recent studies show, the leading role in the escape of solid tumors from the cytotoxic activity of immune cells belongs to the tumor microenvironment (TME). TME consists of several types of cells, including neutrophils, the most numerous cells of the immune system. Recent studies show that the development of the tumor and its ability to metastasize directly affect the extracellular traps of neutrophils (neutrophil extracellular traps,

SUBMITTER: Volkov DV 

PROVIDER: S-EPMC8526190 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature