The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes.

ABSTRACT:

Purpose

Previous studies have investigated the transcriptional modulations of aldosterone overproduction of aldosterone-producing adenomas (APAs). We aimed to systematically study the genes and pathways associated with molecular mechanism underlying APA by bioinformatics analysis and experimental validation for the expression profile.

Methods

This study was performed based on three gene expression profiles (GSE64957, GSE8514, and GSE60042). Differentially expressed gene (DEG) investigation, function and pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed by the bioinformatics analysis. For the validation with quantitative PCR, tissues from 11 patients with nonfunctioning adrenal adenoma (NFA) and 13 with APA were included in our

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8526198 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature