DNA Methylation in Ovarian Tumors-a Comparison Between Fresh Tissue and FFPE Samples.

ABSTRACT: Among women, ovarian cancer (OC) is one of the most severe forms of malignancy, accounting for a low 5-year survival rate, of approximately 52%. Early symptoms are unspecific and hence hard to detect. The origin of OC and its subtypes are still unclear, underlying the need for efficient diagnostic biomarkers. In that regard, epigenetics studies are emerging in cancer diagnostics, with encouraging outcomes. Among them, DNA methylation profiling has shown that the origins of the cancer epigenome are associated with molecular factors that are crucial to carcinogenesis, such as regulation of oncogenes and tumor suppressors. Furthermore, those events have been detected in abnormal cell morphology before neoplastic formation, indicating its potential crucial use in the OC diagnostics in the futu

SUBMITTER: Oliveira DVNP 

PROVIDER: S-EPMC8526488 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature