Dynamic Network Connectivity Reveals Markers of Response to Deep Brain Stimulation in Parkinson's Disease.

ABSTRACT: Background: Neuronal loss in Parkinson's Disease (PD) leads to widespread neural network dysfunction. While graph theory allows for analysis of whole brain networks, patterns of functional connectivity (FC) associated with motor response to deep brain stimulation of the subthalamic nucleus (STN-DBS) have yet to be explored. Objective/Hypothesis: To investigate the distributed network properties associated with STN-DBS in patients with advanced PD. Methods: Eighteen patients underwent 3-Tesla resting state functional MRI (rs-fMRI) prior to STN-DBS. Improvement in UPDRS-III scores following STN-DBS were assessed 1 year after implantation. Independent component analysis (ICA) was applied to extract spatially independent components (ICs) from the rs-fMRI. FC between ICs wa

SUBMITTER: Wu C 

PROVIDER: S-EPMC8526554 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature