Economical droplet-based microfluidic production of [¹⁸F]FET and [¹⁸F]Florbetaben suitable for human use.

ABSTRACT: Current equipment and methods for preparation of radiopharmaceuticals for positron emission tomography (PET) are expensive and best suited for large-scale multi-doses batches. Microfluidic radiosynthesizers have been shown to provide an economic approach to synthesize these compounds in smaller quantities, but can also be scaled to clinically-relevant levels. Batch microfluidic approaches, in particular, offer significant reduction in system size and reagent consumption. Here we show a simple and rapid technique to concentrate the radioisotope, prior to synthesis in a droplet-based radiosynthesizer, enabling production of clinically-relevant batches of [¹⁸F]FET and [¹⁸F]FBB. The synthesis was carried out with an automated synthesizer platform based on a disposable Tef

SUBMITTER: Lisova K 

PROVIDER: S-EPMC8526601 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature