Frequency-specific network activity predicts bradykinesia severity in Parkinson's disease.

ABSTRACT:

Objective

Bradykinesia has been associated with beta and gamma band interactions in the basal ganglia-thalamo-cortical circuit in Parkinson's disease. In this present cross-sectional study, we aimed to search for neural networks with electroencephalography whose frequency-specific actions may predict bradykinesia.

Methods

Twenty Parkinsonian patients treated with bilateral subthalamic stimulation were first prescreened while we selected four levels of contralateral stimulation (0: OFF, 1-3: decreasing symptoms to ON state) individually, based on kinematics. In the screening period, we performed 64-channel electroencephalography measurements simultaneously with electromyography and motion detection during a resting state, finger tapping, hand grasping tasks, and pronation-sup

SUBMITTER: Muthuraman M 

PROVIDER: S-EPMC8526781 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature