Integrated computational analyses reveal novel insights into the stromal microenvironment of SHH-subtype medulloblastoma.

ABSTRACT: Medulloblastoma is the most common malignant brain tumour of childhood. While our understanding of this disease has progressed substantially in recent years, the role of tumour microenvironment remains unclear. Given the increasing role of microenvironment-targeted therapeutics in other cancers, this study was aimed at further exploring its role in medulloblastoma. Multiple computational techniques were used to analyze open-source bulk and single cell RNA seq data from primary samples derived from all subgroups of medulloblastoma. Gene expression is used to infer stromal subpopulations, and network-based approaches are used to identify potential therapeutic targets. Bulk data was obtained from 763 medulloblastoma samples and single cell data from an additional 7241 cells from 23 tumours. I

SUBMITTER: Landry AP 

PROVIDER: S-EPMC8526813 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature