Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws.

ABSTRACT:

Objective

To understand the problems involved in using global OCT measures for detecting progression in early glaucoma.

Subjects/methods

Eyes from 76 patients and 28 healthy controls (HC) had a least two OCT scans at least 1 year apart. To determine the 95% confidence intervals (CI), 151 eyes (49 HC and 102 patients) had at least two scans within 6 months. All eyes had 24-2 mean deviation ≥-6dB. The average (global) thicknesses of the circumpapillary retinal nerve fibre layer (cRNFL), G_ONH, and of the retinal ganglion cell layer plus inner plexiform layer (RGCLP), G_mac, were calculated. Using quantile regression, the 95% CI intervals were determined. Eyes outside the CIs were classified as "progressors." For a reference standard (RS), four experts evalu

SUBMITTER: Sun A 

PROVIDER: S-EPMC8526823 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature