Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals.

ABSTRACT: For their stability and detectability faecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers. However, there is no evidence on how stool miRNA profiles change according to an individual's age, sex, and body mass index (BMI) or how lifestyle habits influence the expression levels of these molecules. We explored the relationship between the stool miRNA levels and common traits (sex, age, BMI, and menopausal status) or lifestyle habits (physical activity, smoking status, coffee, and alcohol consumption) as derived by a self-reported questionnaire, using small RNA-sequencing data of samples from 335 healthy subjects. We detected 151 differentially expressed miRNAs associated with one variable and 52 associated with a

SUBMITTER: Francavilla A 

PROVIDER: S-EPMC8526833 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature