Identification of Components of the Hippo Pathway in Hydra and Potential Role of YAP in Cell Division and Differentiation.

ABSTRACT: The Hippo signaling pathway has been shown to be involved in regulating cellular identity, cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a kinase cascade which determines the nucleo-cytoplasmic localization of YAP in the cell. YAP is the effector protein in the Hippo pathway, which acts as a transcriptional cofactor for TEAD. Phosphorylation of YAP upon activation of the Hippo pathway prevents it from entering the nucleus and abrogates its function in the transcription of the target genes. In Cnidaria, the information on the regulatory roles of the Hippo pathway is virtually lacking. Here, we report the existence of a complete set of Hippo pathway core components in Hydra for the first time. By studying their phylogeny and domain organization, we repor

SUBMITTER: Unni M 

PROVIDER: S-EPMC8526868 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature