Pathologically reduced neural flexibility recovers during psychotherapy of OCD patients.

ABSTRACT: Flexibility is a key feature of psychological health, allowing the individual to dynamically adapt to changing environmental demands, which is impaired in many psychiatric disorders like obsessive-compulsive disorder (OCD). Adequately responding to varying demands requires the brain to switch between different patterns of neural activity, which are represented by different brain network configurations (functional connectivity patterns). Here, we operationalize neural flexibility as the dissimilarity between consecutive connectivity matrices of brain regions (jump length). In total, 132 fMRI scans were obtained from 17 patients that were scanned four to five times during inpatient psychotherapy, and from 17 controls that were scanned at comparable time intervals. Significant negative correl

SUBMITTER: Schiepek G 

PROVIDER: S-EPMC8527047 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature