Association of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes.

ABSTRACT:

Importance

Although tramadol is increasingly used to manage chronic noncancer pain, few safety studies have compared it with other opioids.

Objective

To assess the associations of tramadol, compared with codeine, with mortality and other adverse clinical outcomes as used in outpatient settings.

Design, setting, and participants

Retrospective, population-based, propensity score-matched cohort study using a primary care database with routinely collected medical records and pharmacy dispensations covering more than 80% of the population of Catalonia, Spain (≈6 million people). Patients 18 years or older with 1 or more year of available data and dispensation of tramadol or codeine (2007-2017) were included and followed up to December 31, 2017.

Exposures

New prescri

SUBMITTER: Xie J 

PROVIDER: S-EPMC8527363 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature