Type III CRISPR-Cas Systems: Deciphering the Most Complex Prokaryotic Immune System.

ABSTRACT: The emergence and persistence of selfish genetic elements is an intrinsic feature of all living systems. Cellular organisms have evolved a plethora of elaborate defense systems that limit the spread of such genetic parasites. CRISPR-Cas are RNA-guided defense systems used by prokaryotes to recognize and destroy foreign nucleic acids. These systems acquire and store fragments of foreign nucleic acids and utilize the stored sequences as guides to recognize and destroy genetic invaders. CRISPR-Cas systems have been extensively studied, as some of them are used in various genome editing technologies. Although Type III CRISPR-Cas systems are among the most common CRISPR-Cas systems, they are also some of the least investigated ones, mostly due to the complexity of their action compared to other

SUBMITTER: Kolesnik MV 

PROVIDER: S-EPMC8527444 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature