Comparing Metal-Halide and -Oxygen Adducts in Oxidative C/O-H Activation: Au^III-Cl versus Au^III-OH.

ABSTRACT: High-valent metal-halides have come to prominence as highly effective oxidants. A direct comparison of their efficacy against that of traditional metal-oxygen adducts is needed. [Au^III(Cl)(terpy)](ClO₄)₂ (1; terpy = 2,2':6',2-terpyridine) readily oxidized substrates bearing O-H and C-H bonds via a hydrogen atom transfer mechanism. A direct comparison with [Au^III(OH)(terpy)](ClO₄)₂ (2) showed that 1 was a kinetically superior oxidant with respect to 2 for all substrates tested. We ascribe this to the greater thermodynamic driving force imbued by the Cl ligand versus the OH ligand.

SUBMITTER: Lovisari M 

PROVIDER: S-EPMC8527453 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature