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Therapeutic antibodies - natural and pathological barriers and strategies to overcome them.

ABSTRACT: Antibody-based therapeutics have become a major class of therapeutics with over 120 recombinant antibodies approved or under review in the EU or US. This therapeutic class has experienced a remarkable expansion with an expected acceleration in 2021-2022 due to the extraordinary global response to SARS-CoV2 pandemic and the public disclosure of over a hundred anti-SARS-CoV2 antibodies. Mainly delivered intravenously, alternative delivery routes have emerged to improve antibody therapeutic index and patient comfort. A major hurdle for antibody delivery and efficacy as well as the development of alternative administration routes, is to understand the different natural and pathological barriers that antibodies face as soon as they enter the body up to the moment they bind to their target antigen. In this review, we discuss the well-known and more under-investigated extracellular and cellular barriers faced by antibodies. We also discuss some of the strategies developed in the recent years to overcome these barriers and increase antibody delivery to its site of action. A better understanding of the biological barriers that antibodies have to face will allow the optimization of antibody delivery near its target. This opens the way to the development of improved therapy with less systemic side effects and increased patients' adherence to the treatment.

SUBMITTER: Al Ojaimi Y

PROVIDER: S-EPMC8527648 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Therapeutic antibodies - natural and pathological barriers and strategies to overcome them.

Al Ojaimi Yara Y Blin Timothée T Lamamy Juliette J Gracia Matthieu M Pitiot Aubin A Denevault-Sabourin Caroline C Joubert Nicolas N Pouget Jean-Pierre JP Gouilleux-Gruart Valérie V Heuzé-Vourc'h Nathalie N Lanznaster Débora D Poty Sophie S Sécher Thomas T

Pharmacology & therapeutics 20211020

Antibody-based therapeutics have become a major class of therapeutics with over 120 recombinant antibodies approved or under review in the EU or US. This therapeutic class has experienced a remarkable expansion with an expected acceleration in 2021-2022 due to the extraordinary global response to SARS-CoV2 pandemic and the public disclosure of over a hundred anti-SARS-CoV2 antibodies. Mainly delivered intravenously, alternative delivery routes have emerged to improve antibody therapeutic index a ...[more]

PMID: 34687769

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Dataset Information

Therapeutic antibodies - natural and pathological barriers and strategies to overcome them.

Publications

Therapeutic antibodies - natural and pathological barriers and strategies to overcome them.

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