A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers.

ABSTRACT:

Background

Advanced maternal age (≥35 years) is associated with increased rates of adverse pregnancy outcome. Better understanding of underlying pathophysiological processes may improve identification of older mothers who are at greatest risk. This study aimed to investigate changes in oxidative stress and inflammation in older women and identify clinical and biochemical predictors of adverse pregnancy outcome in older women.

Methods

The Manchester Advanced Maternal Age Study (MAMAS) was a multicentre, observational, prospective cohort study of 528 mothers. Participants were divided into three age groups for comparison 20-30 years (n = 154), 35-39 years (n = 222) and ≥ 40 years (n = 152). Demographic and medical data were collected along with maternal blood samples at 28 and

SUBMITTER: Lean SC 

PROVIDER: S-EPMC8527686 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature