Interaction between PSMD10 and GRP78 accelerates endoplasmic reticulum stress-mediated hepatic apoptosis induced by homocysteine.

ABSTRACT:

Background

The liver plays an important role in production and metabolism of homocysteine (Hcy), which has been reported to be involved in liver injury. In our previous work, we confirm that Hcy can induce liver injury by activating endoplasmic reticulum (ER) stress. However, the underlying mechanisms remain largely unknown.

Results

In present study, we established the Hcy-induced liver injury model by feeding cbs^+/- mice with high methionine diet, and found that a considerable mass of disordered arrangement of hepatocytes and enlarged space between hepatocytes were frequently occurred in the liver of cbs^+/- mice, accompanied with elevated expression levels of apoptosis-related proteins. In addition, Hcy could activate ER stress both in cbs^+/-

SUBMITTER: Xiao K 

PROVIDER: S-EPMC8527788 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature