Dimensional distribution of cortical abnormality across antipsychotics treatment-resistant and responsive schizophrenia.

ABSTRACT:

Background

One-third of patients with schizophrenia are treatment-resistant to non-clozapine antipsychotics (TRS), while the rest respond (NTRS). Examining whether TRS and NTRS represent different pathophysiologies is an important step toward precision medicine.

Methods

Focusing on cortical thickness (CT), we analyzed international multi-site cross-sectional datasets of magnetic resonance imaging comprising 110 patients with schizophrenia (NTRS = 46, TRS = 64) and 52 healthy controls (HCs). We utilized a logistic regression with L1-norm regularization to find brain regions related to either NTRS or TRS. We conducted nested 10-fold cross-validation and computed the accuracy and area under the curve (AUC). Then, we applied the NTRS classifier to patients with TRS, and vice ver

SUBMITTER: Itahashi T 

PROVIDER: S-EPMC8527893 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature