Heterologous SARS-CoV-2 Booster Vaccinations - Preliminary Report.

ABSTRACT:

Background

While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Methods

In this phase 1/2 open-label clinical trial conducted at ten U.S. sites, adults who received one of three EUA Covid-19 vaccines at least 12 weeks prior to enrollment and had no reported history of SARS-CoV-2 infection received a booster injection with one of three vaccines (Moderna mRNA-1273 100-μg, Janssen Ad26.COV2.S 5×10¹⁰ virus particles, or Pfizer-BioNTech BNT162b

SUBMITTER: Atmar RL 

PROVIDER: S-EPMC8528081 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature