Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy.

ABSTRACT: Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely understood. We measured circulating antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, ACE2 displacement and live viral neutralization activities one month following the first and second COVID-19 vaccine doses in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525-935) cells/mm ³ . Nadir CD4+ T-cell counts ranged as low as <10 (median 280; IQR 120-490) cells/mm ³ . After adjustment for sociodemographic, health and vaccine-related variables, HIV infection was significantly associated with 0.2 log ₁₀ lower anti-RBD antibody concentrations (p=0.03)

SUBMITTER: Brumme ZL 

PROVIDER: S-EPMC8528088 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature