Ontology highlight
ABSTRACT:
SUBMITTER: Green AI
PROVIDER: S-EPMC8528209 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Green Adam I AI Burslem George M GM
RSC medicinal chemistry 20210825 10
Discovery of epigenetic chemical probes is an important area of research with potential to deliver drugs for a multitude of diseases. However, commercially available libraries frequently used in drug discovery campaigns contain molecules that are focused on a narrow range of chemical space primarily driven by ease of synthesis and previously targeted enzyme classes (<i>e.g.</i>, kinases) resulting in low hit rates for epigenetic targets. Here we describe the design and synthesis of a compound co ...[more]