Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size.

ABSTRACT: Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.

SUBMITTER: Ismail SD 

PROVIDER: S-EPMC8528395 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature