Capturing an elusive but critical element: Natural protein enables actinium chemistry.

ABSTRACT: Actinium-based therapies could revolutionize cancer medicine but remain tantalizing due to the difficulties in studying and limited knowledge of Ac chemistry. Current efforts focus on small synthetic chelators, limiting radioisotope complexation and purification efficiencies. Here, we demonstrate a straightforward strategy to purify medically relevant radiometals, actinium(III) and yttrium(III), and probe their chemistry, using the recently discovered protein, lanmodulin. The stoichiometry, solution behavior, and formation constant of the ²²⁸Ac³⁺-lanmodulin complex and its ⁹⁰Y³⁺/^natY³⁺/^natLa³⁺ analogs were experimentally determined, representing the first actinium-protein and strongest actinide(III)-pro

SUBMITTER: Deblonde GJ 

PROVIDER: S-EPMC8528432 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature