The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion.

ABSTRACT:

Objective

The voltage-gated potassium channel Kv1.3, which is expressed on activated, disease-associated microglia and memory T cells, constitutes an attractive target for immunocytoprotection after endovascular thrombectomy (EVT). Using young male mice and rats we previously demonstrated that the Kv1.3 blocker PAP-1 when started 12 h after reperfusion dose-dependently reduces infarction and improves neurological deficit on day 8. However, these proof-of-concept findings are of limited translational value because the majority of strokes occur in patients over 65 and, when considering overall lifetime risk, in females. Here, we therefore tested whether Kv1.3 deletion or delayed pharmacological therapy would be beneficial in females and aged animals.

Methods

Transient middle c

SUBMITTER: Chen YJ 

PROVIDER: S-EPMC8528456 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature