Disease progression in Parkinson's disease patients with subjective cognitive complaint.

ABSTRACT:

Objective

Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD-SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI).

Methods

A total of 383 PD patients were enrolled, including 189 PD-NC patients, 59 PD-SCC patients, and 135 PD-MCI patients, with 1-7 years of follow-up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD.

Results

At baseline, PD-SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disea

SUBMITTER: Han LL 

PROVIDER: S-EPMC8528458 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature