Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia.

ABSTRACT:

Objective

To investigate the relationship between the topography of amyloid-β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia.

Methods

We evaluated 154 individuals who were assessed with amyloid-β PET with [¹⁸ F]AZD4694, tau-PET with [¹⁸ F]MK6240, structural MRI, and neuropsychological testing. We also evaluated an independent cohort of 240 individuals who were assessed with amyloid-β PET with [¹⁸ F]Florbetapir, tau-PET with [¹⁸ F]Flortaucipir, structural MRI, and neuropsychological testing. Using the VoxelStats toolbox, we conducted voxel-wise linear regressions between amyloid-PET, tau-PET, and their interaction with cognitive function, correcting f

SUBMITTER: Therriault J 

PROVIDER: S-EPMC8528464 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature